I just discovered something that VLC REALLY didn't like to play. A 4K50fps JPEG2000 YUV444 12bit lossless ~48 GB video that was only 1 minute long.
To be fair the bitrate of the video is insane at ~5700 Mbit/s. The bitrate is so insane that you should really consider using an NVME drive for playback.
MPC-HC could kinda play it but only with extreme stutter and lag. My CPU (Ryzen 9 5900x) was completely maxed out.
I think you need hardware acceleration for a video like this.